2019 Publications

The curcumin analog EF24 is a novel senolytic agent.

Li, W.; He, Y.; Zhang, R.; Zheng, G.; Zhou, D.*
Aging. 2019, 11, 771-782. 10.18632/aging.101787


Cellular senescence and radiation-induced pulmonary fibrosis.

He, Y.; Thummuri, D.; Zheng, G.; Okunieff, P.; Citrin, D. E.; Vujaskovic, Z.; Zhou, D.*
Transl. Res. 2019, 209, 14-21. Doi: 10.1016/j.trsl.2019.03.006


GZ-11608, a vesicular monoamine transporter-2 inhibitor, decreases the neurochemical and behavioral effects of methamphetamine.

Lee, N-R.; Zheng, G.; Leggas, M.; Janganati, V.; Nickell, J. R.; Crooks, P.; Bardo, M. T.; Dwoskin, L. P.*
J. Pharmacol. Exp. Ther. 2019, 371, 526-543. Doi: 10.1124/jpet.119.258699


A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.

Khan, S.; Zhang, X.; Lv, D.; Zhang, Q.; He, Y.; Zhang, P.; Liu, X.; Thummuri, D.; Yuan, Y.; Wiegand, J.S.; Pei, J.; Zhang, W.; Sharma, A.; McCurdy, C. R.; Kuruvilla, V. M.; Baran, N.; Ferrando, A. A.; Kim, Y.; Rogojina, A.; Houghton, P. J.; Huang, G.; Hromas, R.; Konopleva, M.; Zheng, G.;* Zhou, D.*
Nat. Med. 2019, 25, 1938-1947. Doi: 10.1038/s41591-019-0668-z


Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL.

Zhang, X.; Thummuri, D.; He, Y.; Liu, X.; Zhang, P.; Zhou, D.; Zheng, G.*
Chem. Comm. 2019, 55, 14765-14768. Doi: 10.1039/C9CC07217A