Lab Announcements

Here, you can find highlights for Zheng Laboratory and our team from over the past four years.

2021 Announcements

The illustration depicts a chimera labeled PROTAC attacking small, aggressive looking caricatures of labeled BCL-XL and BCL-2. The chimera has a lion head roaring as he crushes a BCL-XL creature beneath his paw, a snake head constricting around a BCL-2 creature, and finally a goat head with his mouth open and tongue out as if mid-yell. In the upper left corner, a BCL-XL and BCL-2 creature hold crossed spears in front of a red, smiling creature labeled Cyst-C.
Illustration from Pratik Pal’s recent manuscript om the discovery of a novel BCL-XL PROTAC degrader published in the Journal of Medicinal Chemistry – click to see full size image
  • SEPTEMBER 2021 | Congratulations to our lab post-doctoral fellow Pratik Pal, PhD, for the publication of his manuscript “Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition” in the Journal of Medicinal Chemistry.
  • JUNE 2021 | Dr. Zheng has been awarded tenure at the University of Florida College of Pharmacy. Congratulations!
  • APRIL 2021 | Pratik Pal has won the Best Oral Presentation Award in the postdoctoral category at the 4th UF Drug Discovery Symposium hosted by the UF College of Pharmacy’s Center for Natural Products, Drug Discovery and Development (CNPD3). The title of his presentation was “Discovery of a BCL-XL/BCL-2 dual function PROTAC.” Congratulations!
  • APRIL 2021 | Zhixing Wu, PhD, has joined the Zheng Lab as an Research Assistant Professor. Welcome!
  • APRIL 2021 | A review article co-authored by Dr. Zheng titled “Therapy-induced senescence: opportunities to improve anti-cancer therapy” has been published in the Journal of the National Cancer Institute. Read more here.
  • MARCH 2021 | Yi Liu, PhD, has joined the Zheng Lab as a postdoctoral fellow. Welcome!
  • MARCH 2021 | Our drug candidate DT2216 has been highlighted in an excellent article titled “Targeted protein degraders crowd into the clinic” by journalist Asher Mullard for Nature Reviews Drug Discovery. Read the article here.
  • MARCH 2021 | DT2216, a PROTAC BCL-XL degrader co-developed with Dr. Daohong Zhou’s Lab at the UF Health Cancer Center, has been cleared for first-in-human phase 1 clinical trial. We are so grateful to all who put in extensive work in our efforts to treat cancers. Read more here.
  • MARCH 2021 | Finn started in the Zheng Lab as an undergraduate research volunteer. Welcome!
  • FEBRUARY 2021 | A paper in collaboration with Dr. Weizhou Zhang’s Lab titled “Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells” is published in Nature Communications. Peiyi and Xuan are co-authors of this paper. Congratulations! Read more here.
  • FEBRUARY 2021 | Matt Burke’s first publication, “A concise synthesis of (S)-δ-CEHC, a metabolite of vitamin E,” has been published in ACS Omega. Congratulations! Read more here.
Scientific illustration from Matt Burke's first publication.
  • JANUARY 2021 | Xingui joined Dr. Alessio Ciulli’s Lab as a postdoctoral fellow. Congratulations and we wish you the best!
  • JANUARY 2021 | Laith Elissa started in the Zheng Lab as a PharmD research volunteer. Welcome!
  • JANUARY 2021 | Michael started in the Zheng Lab as an undergraduate research volunteer. Welcome!

2020 Announcements

  • DECEMBER 2020 | In collaboration with Robert Eoff’s Lab at the University of Arkansas for Medical Sciences, Satheesh and Xingui published an article titled “Facile semisynthesis and evaluation of garcinoic acid and its analogs for the inhibition of human DNA polymerase β” in Molecules. Congratulations! Read more here.
Molecule illustrations of Garcinoic acid and DT3 from Stheesh and Xingui's published paper.
  • DECEMBER 2020 | Xuan started as a Principal Investigator at Shanghai Institute of Materia Medica. Congratulations and we wish you the best!
  • AUGUST 2020 | Peiyi is a leading author of a review article summarizing our recent work on the discovery of BCL-PROTACs, titled “PROTAC is an effective approach to address the platelet toxicity associated with BCL-XL inhibitors,” published in Exploration of Targeted Anti-tumor Therapy. Congratulations! Read more here.
  • AUGUST 2020 | Alexis and Matt joined the Zheng Lab as graduate student assistants. Welcome!
  • JULY 2020 | Yufeng and Xuan published their article titled “Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs” in Chemical Communications in collaboration with Dr. Diaqing Liao. Congratulations! Read more here.
Illustration from Yufeng and Xuan's Chemical Communications article shoing HDACs being broken down through PROTACs
  • MAY 2020 | Xingui published a review titled “Assays and technologies for developing proteolysis targeting chimera degraders” in Future Medicinal Chemistry. Congratulations! Read more here.
Illustration from Xingui's review published in Future Medicinal Chemistry.
  • MAY 2020 | Xuan and Peiyi published an IAP-recruiting BCL-XL PROTAC in their paper titled “Discovery of IAP-Based BCL-XL PROTACs as potent degraders across multiple cancer cell lines” in European Journal of Medicinal Chemistry. Congratulations! Read more here.
Illustration from Xuan and Peiyi's paper published in the European Journal of MEdicinal Chemistry.
  • APRIL 2020 | Our discovery work on the BCL-XL PROTAC degraders titled “Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity” has been published in European Journal of Medicinal Chemistry. Congratulations to Xuan and other authors! Read more here.
Illustration and figures graphic from Xuan's paper published in the European Journal of Medicinal Chemistry.
  • APRIL 2020 | Our collaborative work with Dr. Daohong Zhou’s Lab was published in Nature Communications, titled “Using proteolysis targeting chimera technology to overcome ABT 263 on-target platelet toxicity and improve its senolytic activity.” Congratulations Xuan, Peiyi, Xingui, and all other authors! Read more here.
  • APRIL 2020 | Xingui’s paper titled “Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production” has been published in Bioorganic & Medicinal Chemistry. Congratulations! Read more here.
Illustration from Xingui's paper published in Bioorganic and Medicinal Chemistry
  • FEBRUARY 2020 | Xuan published an editorial titled “Targeting anti-apoptotic BCL-2 family proteins for cancer treatment” in Future Medicinal Chemistry. Congratulations! Read more here.
  • FEBRUARY 2020 | Danny Chen started in the Zheng Lab as an undergraduate research volunteer. Welcome!
  • FEBRUARY 2020 | Our work done in collaboration with Dr. Daohong Zhou’s Lab published in Nature Medicine in December 2019 titled “A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity” was highlighted in AACR Cancer Discovery. Congratulations! Read more here.
  • JANUARY 2020 | Jonathan Costro started in the Zheng Lab pursuing a PharmD Research Elective. Welcome!
  • JANUARY 2020 | Xiaoyang has been admitted to the Chemistry PhD program at Rice University in Houston, Texas. Congratulations and best wishes!
  • JANUARY 2020 | Xingui and Saikat’s paper titled “Synthesis and microsomal metabolic stability studies of a fluorine-substituted δ-tocotrienol derivative” was published in ChemMedChem. Congratulations! Read more here.

2019 Announcements

  • DECEMBER 2019 | Our collaborative work with Dr. Daohong Zhou’s Lab titled “A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity” was published in Nature Medicine. Congratulations to all authors! Read more here.
  • DECEMBER 2019 | Our collaborative work with Dr. Daohong Zhou’s Lab titled “Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL” has been published in Chemical Communications. Congratulations Xuan, Xingui, Peiyi, and others! Read more here.
Illustration from Xuan, Xingui, and Peiyi's paper published in collaboration with Dr. Daohong Zhou's lab in Chemical Communications.
  • SEPTEMBER 2019 | Yufeng has joined the Zheng Lab as a postdoctoral fellow. Welcome!
  • SEPTEMBER 2019 | Jiali Liu started in the Zheng Lab as an undergraduate research volunteer. Welcome!
  • AUGUST 2019 | Saikat Podar has joined the Zheng Lab as a graduate student assistant. Welcome!
  • JULY 2019 | Katherine Zheveleva has started in the Zheng Lab as a PharmD research volunteer. Welcome!
  • JUNE 2019 | Matt has joined the Zheng Lab as a summer research intern. Welcome!
  • MAY2019 | Abelardo Montalvo has joined the Zheng Lab as a selected participant of the Intensive Summer Research Program. Welcome!

2018 Announcements

  • JULY 2018 | Dr. Xuan “Vick” Zhang has been promoted to Assistant Professor. Congratulations!
  • JULY 2018 | Wanyi has joined the Zheng Lab as a research technician. Welcome!
  • JUNE 2018 | The Zheng Lab has relocated to the University of Florida from the University of Arkansas for Medical Sciences.