2021 Publications

Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model

Nemec-Bakk, A. S.*; Sridharan, V.; Landes, R. D.; Singh, P.; Cao, M.; Seawright, J. W.; Liu, X.; Zheng, G.; Dominic, P.; Pathak, R.; Boerma, M.
Life Sciences in Space Research. 2021, 31, 43-50. Doi: 10.1016/j.lssr.2021.07.006


Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

Lv, D.; Pal, P.; Liu, X.; Jia, Y.; Thummuri, D.; Zhang, P.; Hu, W.; Pei, J.; Zhang, Q.; Zhou, S.; Khan, S.; Zhang, X.; Hua, N.; Yang, Q.; Arango, S.; Zhang, W.; Nayak, D.; Olsen, S. K.; Weintraub, S. T.; Hromas, R.; Konopleva, M.; Yuan, X.*; Zheng, G.*; Zhou, D.*
Nature Communications. 2021, 12, 6896. Doi: 10.1038/s41467-021-27210-x


Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition

Pal, P.; Thummuri, D.; Lv, D.; Liu, X.; Zhang, P.; Hu, W.; Poddar, S.K.; Hua, N.; Khan, S.; Yuan, Y.; Zhang, X.; Zhou, D.*; Zheng, G.*
Journal of Medicinal Chemistry. 2021, 64(19), 14230-14246. Doi: 10.1021/acs.jmedchem.1c00517


Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6.

Gong, S.; Maegawa, S.; Gopalakrishnan, V.;* Zheng, G.;* Cheng, D.*
Biochemical Journal. 2021, 478, 389-406. Doi: 10.1042/BCJ20200411


A concise synthesis of (S)-δ-CEHC, a metabolite of vitamin E.

Burke, M.; Pal, P.; Zhang, P.; Zhang, X.;* Zheng, G.
ACS Omega. 2021, 6, 4355-4361. Doi: 10.1021/acsomega.0c05658


Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells.

Kolb, R.; De U.; Khan, S.; Luo, Y.; Kim, M-C.; Yu, H.; Wu, C.; Mo, J.; Zhang, Xin; Zhang, P.; Zhang, Xuan.; Borcherding, N.; Koppel, D.; Fu, Y-X.; Zheng, S.; Avram, D.; Zheng, G.; Zhou, D.; Zhang, W.*
Nature Communications. 2021, 12, 1281. Doi: 10.1038/s41467-021-21573-x


Therapy-induced senescence: opportunities to improve anti-cancer therapy.

Prasanna, P. G.;* Citrin, D. E.; Hildesheim, J.; Ahmed, M. M.; Venkatachalam, S.; Riscuta, G.; Xi, D.; Zheng, G.; van Deursen, J.; Goronzy, J.; Kron, S. J.; Anscher, M. S.; Sharpless, N. E.; Campisi, J.; Brown, S. L.; Niedernhofer, L. J.; O’Loghlen, A.; Georgakilas, A. G.; Paris, F.; Gius, D.; Gewirtz, D. A.; Schmitt, C. A.; Abazeed, M. E.; Kirkland, J. L.; Richmond, A.; Romesser, P. B.; Lowe, S. W.; Gil, J.; Mendonca, M. S.; Burma, S.; Zhou, D.; Coleman, C. N.
Journal of the National Cancer Institute. 2021. In Press. Doi: 10.1093/jnci/djab064